Zocef/Zocef Kids/Zocef Hospi Drug Interactions

Zocef: Suspension: Probenecid reduces the renal clearance of cefuroxime.
Zocef Kids: Drugs which reduce gastric acidity may result in a lower bioavailability of Cefuroxime (as axetil) compared with that of the fasting state and tend to cancel the effect of enhanced post-prandial absorption.
In common with other antibiotics, Cefuroxime (as axetil) may affect the gut flora, leading to lower oestrogen reabsorption and reduced efficacy of combined oral contraceptives.
As a false negative result may occur in the ferricyanide test, it is recommended that either the glucose oxidase or hexokinase methods are used to determine blood/plasma glucose levels in patients receiving Cefuroxime (as axetil). This antibiotic does not interfere in the alkaline picrate assay for creatinine.
Zocef Hospi: Cefuroxime may affect the gut flora, leading to lower oestrogen reabsorption and reduced efficacy of combined oral contraceptives.
Cefuroxime is excreted by glomerular filtration and tubular secretion. Concomitant use of probenecid is not recommended. Concurrent administration of probenecid prolongs the excretion of cefuroxime and produces an elevated peak serum level.
Potential nephrotoxic drugs and loop diuretics: High-dosage treatments with cephalosporins should be carried out with caution on patients who are taking strong-acting diuretics (such as furosemide) or potential nephrotoxic preparations (such as aminoglycoside antibiotics), since impairment of renal function through such combinations cannot be ruled out.
Other Interactions: Determination of blood/plasma glucose levels.
Concomitant use with oral anticoagulants may give rise to increased international normalised ratio (INR).